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Education

Research Interests

Dr. Lokeshwar’s lab focuses on biomarkers and experimental therapeutics related to bladder and renal cell carcinomas (RCC) with some work on prostate cancer, and benign prostatic hyperplasia (BPH) . Her earlier work was on the invention of HA-HAase urine test for detecting bladder cancer. This work is widely recognized and led to the incorporation of hyaluronidase in textbooks. This work ties in with the newest discovery from her laboratory about the “Chase test” for bladder cancer and biomarker-guided evidence-based treatment combinations to overcome chemoresistance in advanced bladder cancer.

Education

Ph.D. in Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA -- 2016

B.A. in Neuroscience and Behavior, Wesleyan University, Middletown, CT -- 2010

Research Interests

Parkinson’s disease, neurodegeneration, aging, microbiome in disease. 

Education 

MD Beijing Medical University, Beijing, China -- 1995 
MS Truman State University, Kirksville, MO, USA -- 2001 
PhD University of Tennessee, Knoxville, TN, USA -- 2006
Postdoctoral Associate, Duke University Medical Center, Durham NC, USA -- 2010 

Research Interests

Research focused on understanding the molecular mechanisms and pathogenesis of two vision-related disorders: keratoconus (KC) and glaucoma. KC, a progressive thinning of the cornea, is the most common corneal ectasia, affecting one in every 500 to 2000 Americans. KC causes moderate to severe astigmatism, nearsightedness, swelling and cornea scarring. It is necessary for 10-20% KC patients to have cornea transplants. Using whole exome and whole genome sequencing, we have identified novel mutations in multiplex KC families. We are characterizing these mutations using primary human corneal cells and transgenic mouse models. We have research collaborations with investigators from California, Iowa, Illinois, Saudi Arabia, Israel, and Duke University in North Carolina. Glaucoma is the leading cause of irreversible blindness worldwide, affecting over 60 million people. It is characterized as a progressive loss of retinal ganglion cells and visual field. 

Education

University of Puerto Rico School of Medicine

San Juan VA Hospital- Internal Medicine

Yale School of Medicine- Endocrinology and Metabolism 

Research Interests

Epigenetic changes induced by aging and their impact on mesenchymal stem cell function and tissue regeneration.